Down-regulation of Laminin and its Correlated Significance to Interstitial Cells of Cajal in Hirschsprung's Disease
Laminin supports ICC viability and prevents apoptosis. Reduced laminin expression in HSCR contributes to the loss of ICC, disrupting pacemaker activity and impairing colonic motility.
Authors
- Yaru Mou
- Qinghao Li (ORCID: https://orcid.org/0000-0002-5498-5066)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9482-5227)
- Dongming Wang (ORCID: https://orcid.org/0000-0001-5547-1473)
- Jing Gao
Institutions
- Qingdao University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Taian City Central Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Current Stem Cell Research & Therapy
- Published
- 2025-08-12
- DOI
- https://doi.org/10.2174/011574888x379509250805102539
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00