Novel Benzimidazole-Thiazolidine-2,4-dione Hybrid Compounds as Promising PPAR-γ Modulators with Antidiabetic Activity: Design, Synthesis, Molecular Docking, and In Vitro Evaluation

Compounds PT14 and PT18 are promising candidates to investigate further, as they exhibit significant cell viability, glucose uptake, and PPAR-γ transcription factor activation in nuclear extracts. These encouraging findings warrant further exploration through in vivo pharmacokinetic and antidiabetic efficacy studies, which will help establish their therapeutic potential and safety profile in biological systems.