Timosaponin A-III Induces ROS-mediated Apoptosis and Triggers Protective Autophagy <i>via</i> the AMPK/mTOR Pathway in Prostate Cancer
TAIII induced ROS-mediated cell apoptosis and promoted cytoprotective autophagy via the AMPK/mTOR pathway in PCa. These findings may provide a new strategy for combining TAIII with CQ together for PCa treatment.
Authors
- Juntao Li
- Dejuan Wang (ORCID: https://orcid.org/0000-0002-4877-1213)
- Jianguang Qiu (ORCID: https://orcid.org/0000-0002-3517-4110)
- Jianjian Wu
- Chutian Xiao (ORCID: https://orcid.org/0000-0002-2873-1310)
- Qiong Wu (ORCID: https://orcid.org/0000-0003-3305-6652)
- Qiang Guo
- Yifei Zhang (ORCID: https://orcid.org/0000-0003-3288-6195)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Twelfth Guangzhou City People's Hospital (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-08-18
- DOI
- https://doi.org/10.2174/0118715206389520250805135535
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.00