Post-marketing Safety Surveillance of Drug-induced Dementia: Utilizing Signal Detection and Mendelian Randomization in Spontaneous Reports

The adverse event data sourced from the FAERS database indicate that certain medications are associated with an increased risk of developing dementia, a finding corroborated by our Mendelian randomization analysis. Establishing a comprehensive monitoring and risk assessment program is crucial for identifying high-risk individuals and facilitating informed medication choices, thereby potentially reducing the incidence of dementia.