A Phase-II Investigator-Initiated Randomized, Double-Blind, Parallel-Group Clinical Trial of 5-Aminolevulinic Acid Hydrochloride/Sodium Ferrous Citrate (5-ALA-HCl/SFC) for Patients With Adult-Onset Still’s Disease (AOSD) Refractory to Corticosteroids
Efficacy signals were observed, especially in the high-dose group; however, the small sample size precludes definitive conclusions. Further research is required to confirm this.
Authors
- Shuzo Sato (ORCID: https://orcid.org/0000-0002-8110-8261)
- Hiroshi Yamamoto (ORCID: https://orcid.org/0000-0002-1739-1226)
- Tomohiro Koga (ORCID: https://orcid.org/0000-0003-2077-4428)
- Noriyoshi Ogawa
- Motomu Hashimoto (ORCID: https://orcid.org/0000-0002-9241-060X)
- Remi Sumiyoshi (ORCID: https://orcid.org/0009-0005-4814-7137)
- Yoko Hattori (ORCID: https://orcid.org/0000-0002-5989-9554)
- Kiyoshi Migita (ORCID: https://orcid.org/0000-0003-1339-5622)
- Shimpei Morimoto (ORCID: https://orcid.org/0000-0002-5340-6851)
- Hideki Hanaoka (ORCID: https://orcid.org/0000-0003-0186-9296)
- Yosuke Inaba (ORCID: https://orcid.org/0000-0002-8659-2873)
- Naoki Hosogaya (ORCID: https://orcid.org/0000-0002-3229-2277)
- Tamiki Hikake
- Atsushi Kawakami (ORCID: https://orcid.org/0000-0002-1512-8782)
- Osamu Kamisawa
- Mariko Kawakami
- Tomoya Kurokawa
Institutions
- Chiba University Hospital (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-08-17
- DOI
- https://doi.org/10.7759/cureus.90354
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Keio University
- Hokkaido University
- University of Tsukuba