Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis
Trajectories of craving/drug use in clinical trials for cocaine use disorder are heterogeneous. Participants experiencing the greatest reduction in cocaine craving/use experienced the greatest improvement in other measures of drug use and psychosocial functioning, supporting the utility of reduced craving/use as a clinically relevant outcome in pharmacotherapy trials of people with cocaine use disorder.
Authors
- Cecilia L. Bergeria (ORCID: https://orcid.org/0000-0002-8183-1273)
- Masoumeh Amin‐Esmaeili
- Ramin Mojtabai (ORCID: https://orcid.org/0000-0002-2134-4043)
- Lorenzo Leggio (ORCID: https://orcid.org/0000-0001-7284-8754)
- Ryoko Susukida (ORCID: https://orcid.org/0000-0003-0444-5368)
- Kelly E. Dunn (ORCID: https://orcid.org/0000-0003-3746-3108)
- Trang Quynh Nguyen (ORCID: https://orcid.org/0000-0003-1653-5491)
- Mehdi Farokhnia (ORCID: https://orcid.org/0000-0003-0902-4212)
Institutions
- University of Maryland, Baltimore (US)
- National Institute on Drug Abuse (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Tulane Medical Center (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
Publication Details
- Journal
- Drug and Alcohol Dependence
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.drugalcdep.2025.112841
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse