Deciphering cellular heterogeneity and pathway dynamics in urinary samples: a UMAP-Based approach to understanding acute kidney injury
Our findings provide evidence that MAPK1 is upregulated in urinary mononuclear cells of AKI patients and plays a key role in regulating ECM-related pathways. MAPK1 could serve as a potential biomarker for AKI diagnosis and prognosis and may represent a promising therapeutic target for limiting ECM remodeling and fibrosis in AKI. Further studies are needed to explore the clinical implications of targeting MAPK1 in AKI treatment.
Authors
- Yaping Xiang (ORCID: https://orcid.org/0000-0002-5591-8690)
- Yuan Cheng (ORCID: https://orcid.org/0000-0002-0226-614X)
- Juan Wu (ORCID: https://orcid.org/0009-0009-9385-7452)
- Lihua Ni
Institutions
- China Three Gorges University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Third Hospital (CN)
- Yichang Central People's Hospital (CN)
- Hubei Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fphar.2025.1573469
- Citations
- 1
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Wuhan University
- Zhongnan Hospital of Wuhan University