Neutrophil-Related Genes Predict Prognosis and Contribute to Immunosuppression in Acute Myeloid Leukemia
This study advances a novel 5-gene prognostic model integrating neutrophil biology into AML risk stratification. CD37, a key regulator of immune evasion, serves as a dual biomarker for prognosis and immunotherapy prediction. While validated across multiple cohorts, experimental studies are warranted to unravel CD37's mechanistic role. Our findings highlight the potential of neutrophil-centric biomarkers in guiding personalized AML therapy.
Authors
- Xiaomin Liu (ORCID: https://orcid.org/0000-0003-2155-3627)
- Di Zhang (ORCID: https://orcid.org/0000-0002-4831-0521)
- Jingru Zhang (ORCID: https://orcid.org/0000-0003-1061-1246)
- Tingting Liu (ORCID: https://orcid.org/0000-0002-8179-6180)
- Yongjian Li (ORCID: https://orcid.org/0000-0003-3606-8245)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Blood and Lymphatic Cancer Targets and Therapy
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/blctt.s529074
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00