Clinical characteristics, complications and outcomes of critically ill patients with Dengue in Brazil, 2012-2024: A nationwide, multicenter cohort study
We described a large cohort of dengue patients admitted to ICUs and identified key risk factors for severe dengue complications, such as advanced age, presence of comorbidities, higher level of leukocytes, and lower level of platelets. The proposed prediction tool can be used for early identification and targeted interventions to improve outcomes in dengue-endemic regions.
Authors
- Otávio T. Ranzani (ORCID: https://orcid.org/0000-0002-4677-6862)
- Esteban García-Gallo (ORCID: https://orcid.org/0000-0002-8030-9985)
- Tom Edinburgh (ORCID: https://orcid.org/0000-0002-3599-7133)
- Leonardo dos Santos Lourenço Bastos (ORCID: https://orcid.org/0000-0001-7833-0403)
- Sílvio Hamacher (ORCID: https://orcid.org/0000-0002-3980-0342)
- Igor Tona Peres (ORCID: https://orcid.org/0000-0001-9863-4690)
- Fernando A. Bozza (ORCID: https://orcid.org/0000-0003-4878-0256)
Institutions
- Pontifícia Universidade Católica do Rio de Janeiro (BR)
- University of Oxford (GB)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.ijid.2025.108023
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Pontifícia Universidade Católica do Rio de Janeiro
- Agencia Estatal de Investigación
- European Social Fund