COL10A1+ fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevance
Our study identifies a CAF subpopulation, COL10A1<sup>+</sup>Fib, associated with CRC progression and immune suppression, suggesting it as a potential therapeutic target in CRC and possibly other malignancies.
Authors
- Jian Qin (ORCID: https://orcid.org/0000-0002-7701-9661)
- Shangshang Hu (ORCID: https://orcid.org/0009-0009-3828-9907)
- Shukui Wang (ORCID: https://orcid.org/0000-0001-6972-2587)
- Junjie Nie (ORCID: https://orcid.org/0000-0002-4384-2289)
- Xinliang Gu (ORCID: https://orcid.org/0000-0001-8493-5951)
- Yuqin Pan (ORCID: https://orcid.org/0000-0003-4028-6835)
- Zixuan Liu (ORCID: https://orcid.org/0009-0008-6387-8335)
- Yue Li (ORCID: https://orcid.org/0000-0001-8198-9911)
- Mu Xu
- Tao Xu (ORCID: https://orcid.org/0000-0001-7544-0551)
- Yuhan Chen (ORCID: https://orcid.org/0000-0002-2950-2675)
- Jinwei Lou
- Huiling Sun
- Muzi Ding
Institutions
- China Pharmaceutical University (CN)
- Jiangsu Cancer Hospital (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s13046-025-03510-8
- Citations
- 8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.38
Funders
- National Natural Science Foundation of China
- Key Project of Science and Technology Development of Nanjing Medicine