SIRPα extracellular domain shed from neutrophils by ADAM10 aggravates sepsis via initiating nitric oxide release from erythrocyte
These findings identify shedding SIRPα-ex as a key exacerbating factor in sepsis via NO-mediated vascular dysfunction. Targeting SIRPα-ex shedding offers a potential therapeutic strategy for mitigating sepsis.
Authors
- Shuang Qu (ORCID: https://orcid.org/0009-0008-9889-3383)
- Zhen Bian (ORCID: https://orcid.org/0000-0003-3409-9240)
- Hongwei Liang (ORCID: https://orcid.org/0000-0003-1086-3718)
- Lei Shi (ORCID: https://orcid.org/0000-0002-6631-6732)
- Ke Zen (ORCID: https://orcid.org/0000-0002-5166-2974)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-0535-0600)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1834-2119)
- Geng Lu (ORCID: https://orcid.org/0000-0003-3420-1890)
Institutions
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.019
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- National Institutes of Health
- National Key Research and Development Program of China