Prevalence and Factors Associated with Tuberculosis Among Healthcare Workers: A Systematic Review with Meta-Analysis
Background: Healthcare workers are exposed to an unhealthy environment that increases the risk of developing tuberculosis. Objective: To analyze the prevalence and factors associated with tuberculosis among healthcare workers. Methods: A systematic review with meta-analysis was conducted using six databases. Methodological quality was assessed according to JBI recommendations. A random-effects meta-analysis was performed. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed for reporting. Results: Thirty-two articles were included in the evidence synthesis. The prevalence of tuberculosis among healthcare workers was found to be 15.92% [95% CI 8.49–27.88|I2 = 99% | p = 0]. Female sex was associated with 1.37 times higher odds of infection [95% CI 0.68–2.38, I2 = 80%, p = 0.01]. Advanced age increased the odds by 1.47 times [95% CI 1.33–4.62, I2 = 76%, p = 0.01]. Conclusions: Early diagnosis of tuberculosis in the workplace and the implementation of continuing education programs with preventive strategies are essential to control contamination and the spread of the disease: CRD42022320153.
Authors
- Thaís Zamboni Berra (ORCID: https://orcid.org/0000-0002-4163-8719)
- Felipe Mendes Delpino (ORCID: https://orcid.org/0000-0002-3562-3246)
- Oclaris Lopes Munhoz (ORCID: https://orcid.org/0000-0001-8901-7148)
- Flávia Meneguetti Pieri (ORCID: https://orcid.org/0000-0003-1239-2550)
- Alessandro Rolim Scholze (ORCID: https://orcid.org/0000-0003-4045-3584)
- Yan Mathias Alves (ORCID: https://orcid.org/0000-0002-5596-0047)
- Maria José Quina Galdino (ORCID: https://orcid.org/0000-0001-6709-3502)
- Emiliana Cristina Melo (ORCID: https://orcid.org/0000-0003-1013-4574)
- Mariane Cândido da Silva
- Ricardo Alexandre Arcêncio (ORCID: https://orcid.org/0000-0003-4792-8714)
- Josilene Dália Alves (ORCID: https://orcid.org/0000-0001-5007-9536)
- Mellina Yamamura (ORCID: https://orcid.org/0000-0001-5228-8788)
- Júlia Trevisan Martins (ORCID: https://orcid.org/0000-0003-2208-2281)
- Paola Obreli Bersi (ORCID: https://orcid.org/0000-0001-9628-6469)
Institutions
- Universidade Estadual de Londrina (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade Federal de São Carlos (BR)
- Universidade de São Paulo (BR)
- Universidade Federal de Mato Grosso (BR)
- Universidade Federal de Santa Maria (BR)
- Hospital Bandeirantes (BR)
Publication Details
- Journal
- Microbiology Research
- Published
- 2025-08-16
- DOI
- https://doi.org/10.3390/microbiolres16080191
- Primary Topic
- Infection Control and Ventilation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Division of Graduate Education