FOXO4-AR crosstalk in PCOS: A pivotal mechanism of anovulation
Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine and metabolic disorder in women characterized by hyperandrogenism, ovulatory disorder, and polycystic ovary, affecting approximately 11%–13% women worldwide.1 However, the underlying mechanisms of the ovulatory dysfunction in PCOS remain incompletely understood, hindering the development of effective treatment strategies.
Authors
- Mingjie Fan (ORCID: https://orcid.org/0000-0002-2930-9998)
- Shiqing Qian
- G.W. Pan
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Molecular Therapy — Nucleic Acids
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.omtn.2025.102663
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province
- Natural Science Foundation of Zhejiang Province