Mice harboring the obesity-associated SNP rs1421085 exhibit increased body weight and reveal an IRX3 neuronal circuit regulating body weight
These data demonstrate that OA-SNP<sup>rs142/rs142</sup> mice recapitulate the body weight phenotype associated with rs1421085 in humans and that increased IRX3 in the posterior hypothalamus, as seen in OA-SNP<sup>rs142/rs142</sup> mice, is sufficient to drive some of the metabolic effects of the SNP.
Authors
- Kamal Rahmouni (ORCID: https://orcid.org/0000-0001-5136-6748)
- Andrew I. Sullivan (ORCID: https://orcid.org/0000-0003-4430-3540)
- Matthew J. Potthoff (ORCID: https://orcid.org/0000-0001-9158-5128)
- Kristin E. Claflin
- Kyle H. Flippo (ORCID: https://orcid.org/0000-0001-9667-7056)
- Donald A. Morgan (ORCID: https://orcid.org/0000-0003-3167-1643)
- Meghan C. Naber
- İltan Aklan (ORCID: https://orcid.org/0000-0002-5198-3559)
Institutions
- University of Iowa (US)
- Fraternal Order of Eagles (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.molmet.2025.102234
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- U.S. Department of Veterans Affairs
- National Institute of Diabetes and Digestive and Kidney Diseases