An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure
ERV resurgence is a specific molecular trait of HF, driven by TRIM28 depletion in cardiomyocytes. ERV resurgence activates the innate immune TLR7/9-NF-κB pathway and induces myocarditis and HF. Inception of ERVs and the ERV-mediated immune pathway confers cardiac protection. These results identify TRIM28-ERV-TLR7/9-NF-κB as a target for therapeutic management of myocarditis and HF.
Authors
- Alex F. Chen (ORCID: https://orcid.org/0000-0002-9792-0916)
- Aijun Sun (ORCID: https://orcid.org/0000-0003-1488-0937)
- Yelan Li (ORCID: https://orcid.org/0000-0003-2152-7648)
- Xiaoling Guo (ORCID: https://orcid.org/0000-0003-3153-6249)
- Dao Wen Wang (ORCID: https://orcid.org/0000-0002-9774-3980)
- Ping Yang (ORCID: https://orcid.org/0000-0002-5072-8185)
- Chen Chen (ORCID: https://orcid.org/0000-0001-5080-9383)
- Jun‐Tao Lin (ORCID: https://orcid.org/0000-0002-0492-1021)
- Junhao Xiong
- Gengze Wu (ORCID: https://orcid.org/0000-0002-1992-5308)
- Zilong Geng (ORCID: https://orcid.org/0009-0009-3140-1214)
- Dan Zhu (ORCID: https://orcid.org/0000-0001-6241-4354)
- Bing Zhang (ORCID: https://orcid.org/0000-0002-8836-7178)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-5612-1387)
- Kun Sun (ORCID: https://orcid.org/0000-0002-0504-7372)
- Kang Cheng (ORCID: https://orcid.org/0000-0002-3114-271X)
- Chunyu Zeng (ORCID: https://orcid.org/0000-0003-0173-5028)
- Shasha Zhang (ORCID: https://orcid.org/0000-0003-3431-7615)
- Xiao Cheng (ORCID: https://orcid.org/0000-0002-6602-7463)
- Yuliang Feng (ORCID: https://orcid.org/0000-0002-7997-163X)
- Xumin Hou (ORCID: https://orcid.org/0000-0001-7619-1534)
- Yuze Wang (ORCID: https://orcid.org/0000-0002-0500-3644)
- Yang Sheng (ORCID: https://orcid.org/0000-0003-3380-1966)
- Shuo Wu (ORCID: https://orcid.org/0000-0003-3684-4363)
- Huan Hu (ORCID: https://orcid.org/0000-0002-9677-5745)
- Yige Li (ORCID: https://orcid.org/0000-0002-9904-3611)
- Ruogu Li (ORCID: https://orcid.org/0000-0002-0608-524X)
- Xing Liu
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- Southern University of Science and Technology (CN)
- Daping Hospital (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Institute of Human Genetics (PL)
- Tongji Hospital (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1161/circulationaha.125.074845
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39