Survival following intentional overdose of veterinary insulin: A case report

A 40-year-old man presented to the emergency department within 6 h of a massive overdose of 500 units of long-acting feline glargine insulin intravenously and an estimated 50 mg of clozapine. Upon initial assessment, his Glasgow Coma Scale (GCS) was 15 and his blood sugar level was 45 mg/dL. The patient was successfully managed with dextrose infusions and close monitoring of blood sugar and electrolytes. To date, no cases have been documented in the literature describing an overdose of insulin formulation intended for veterinary use. Cases of overdose with animal-prescribed human insulin analogs can be managed similarly to previously reported cases of human insulin overdose.

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Publication Details

Journal
Toxicology Reports
Published
2025-08-18
DOI
https://doi.org/10.1016/j.toxrep.2025.102114
Citations
1
Primary Topic
Poisoning and overdose treatments
Type
article
Field-Weighted Citation Impact
2.25
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Survival following intentional overdose of veterinary insulin: A case report

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Survival following intentional overdose of veterinary insulin: A case report

Michael Kalinoski, James V. Harmon, Sergey Karachenets, Raza Khan, Pravin Meshram, Elsa Sandeno, Kourtney Zehlke
article en
1 citations

Abstract

A 40-year-old man presented to the emergency department within 6 h of a massive overdose of 500 units of long-acting feline glargine insulin intravenously and an estimated 50 mg of clozapine. Upon initial assessment, his Glasgow Coma Scale (GCS) was 15 and his blood sugar level was 45 mg/dL. The patient was successfully managed with dextrose infusions and close monitoring of blood sugar and electrolytes. To date, no cases have been documented in the literature describing an overdose of insulin formulation intended for veterinary use. Cases of overdose with animal-prescribed human insulin analogs can be managed similarly to previously reported cases of human insulin overdose.

Toxicology ReportsVol. 15
University of Minnesota Medical Center (US), Fairview Ridges Hospital (US)
Zero hunger
Openalex Percentile: Top 11%
Poisoning and overdose treatments
2.25
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