Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by SPP1+ macrophages
Our exploratory analysis reveals how genetic variants may predispose arrhythmia patients to inflammatory and fibrotic processes. These findings may help guide future research into the molecular mechanisms underlying arrhythmia progression to structural heart disease and identify candidate pathways for therapeutic investigation.
Authors
- Rong Xiang (ORCID: https://orcid.org/0000-0003-3487-7348)
- Jie‐Yuan Jin (ORCID: https://orcid.org/0000-0003-3140-2216)
- Yao Deng
- Shuai Guo (ORCID: https://orcid.org/0009-0004-2988-5663)
- Yujie Jiang (ORCID: https://orcid.org/0000-0003-4031-2781)
- Liang Chen (ORCID: https://orcid.org/0000-0002-7985-4273)
- Zhao Wang (ORCID: https://orcid.org/0000-0002-6820-7505)
- Yaqin Chen (ORCID: https://orcid.org/0000-0003-3319-7201)
Institutions
- Central South University (CN)
- Shaoxing University (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Jiangmen Central Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fcell.2025.1611663
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39