Extracellular vesicles-delivered circDB promotes ischemic muscle repair through the miR-34a/USP7/Notch1 signaling pathway
Extracellular vesicles circDB enhances ischemic muscle repair by modulating the miR-34a/USP7/Notch1 pathway. These findings highlight a novel mechanism by which UMSC-derived extracellular vesicles facilitate muscle regeneration and suggest a promising therapeutic approach for lower limb ischemic diseases.
Authors
- Weiliang Wu
- Qingjian Han (ORCID: https://orcid.org/0000-0001-6641-7499)
- Anqi Zhou (ORCID: https://orcid.org/0000-0001-9358-3054)
- Wenjie Chen (ORCID: https://orcid.org/0000-0003-1659-4918)
- Ao Li (ORCID: https://orcid.org/0000-0003-4439-6361)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
- Huiling Zhang (ORCID: https://orcid.org/0009-0006-9327-1804)
- Yan Xu
- Yangxin Li (ORCID: https://orcid.org/0000-0002-2364-3207)
- Lijuan Jiao
- Tonggan Lu
Institutions
- Central South University (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.reth.2025.08.009
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Radiation Medicine and Protection