<scp>IL</scp>‐4‐<scp>JAK1</scp>‐<scp>STAT6</scp> Pathway Mediates Electroacupuncture's Effect on Microglial <scp>M2</scp> Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression
IL-4-JAK1-STAT6 signaling may be an important pathway in mediating the efficacy of electroacupuncture in IBD with comorbid depression, particularly promoting microglial M2 polarization and improving neuroinflammation.
Authors
- Zhanwei Xu (ORCID: https://orcid.org/0000-0003-0830-5258)
- Z. Li (ORCID: https://orcid.org/0009-0005-5833-1130)
- Yuxiang Huang (ORCID: https://orcid.org/0000-0003-1329-8814)
- Sihui Cao
- Jingjing Yang (ORCID: https://orcid.org/0000-0002-3414-0621)
- Mi Liu (ORCID: https://orcid.org/0000-0003-4860-7533)
- Jin Liu (ORCID: https://orcid.org/0009-0003-6023-9961)
- Qiong Liu (ORCID: https://orcid.org/0000-0002-5634-1555)
- Peicheng Lu (ORCID: https://orcid.org/0009-0001-2983-029X)
- Jia Lv
- Lin Chen (ORCID: https://orcid.org/0000-0002-6666-2483)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/cns.70572
- Citations
- 6
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- National Natural Science Foundation of China
- Hunan University
- Natural Science Foundation of Hunan Province
- Hunan University of Chinese Medicine