Role of the Locus Coeruleus in Response to Threat in Anxiety Disorders and Posttraumatic Stress Disorder: An Ultra-High-Field 7T Functional Magnetic Resonance Imaging Study
This translational and dimensional work advances our understanding of the role of the LC system and threat circuitry in pathological anxiety. Using 7T MRI, this study highlights the functional role of the LC in processing unpredictable threat in association with anxious arousal in individuals with anxiety disorders and PTSD.
Authors
- D. Smith
- Dennis S. Charney (ORCID: https://orcid.org/0000-0003-0610-3433)
- James W. Murrough (ORCID: https://orcid.org/0000-0001-6286-1242)
- Christian Grillon (ORCID: https://orcid.org/0000-0002-0625-260X)
- Vicki Soogrim
- Yael Jacob (ORCID: https://orcid.org/0000-0003-3278-9264)
- Sarah Rutter (ORCID: https://orcid.org/0000-0003-0114-4295)
- Priti Balchandani (ORCID: https://orcid.org/0000-0001-7709-5835)
- Philipp T. Neukam (ORCID: https://orcid.org/0000-0002-9442-0043)
- Prantik Kundu (ORCID: https://orcid.org/0000-0001-9367-3068)
- Laurel S. Morris (ORCID: https://orcid.org/0000-0002-5862-6650)
- Nicholas L. Balderston (ORCID: https://orcid.org/0000-0002-8565-1544)
- Adriana Feder (ORCID: https://orcid.org/0000-0003-2931-310X)
- Sarah Boukezzi (ORCID: https://orcid.org/0000-0003-4575-3412)
- Yolanda Irini Whitaker
Institutions
- National Institutes of Health (US)
- James J. Peters VA Medical Center (US)
- Center for Discovery (US)
- National Institute of Mental Health (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100596
- Citations
- 3
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.29