<scp>PRG</scp>‐1 Relieves Neonatal Stimuli‐Induced Hyperalgesia and Anxiety via Stage‐Specific Synapse Remodeling
Our findings suggest that PRG-1 relieves RNS-induced persistent hyperalgesia, anxiety, and pain-perception memory via synapse remodeling at different stages. Targeting PRG-1-mediated synaptic remodeling may provide a novel neuroprotective strategy for preventing chronic pain comorbidities with anxiety disorders following early-life pain exposure.
Authors
- Song Cao (ORCID: https://orcid.org/0000-0003-4619-9441)
- Xingfeng Liu (ORCID: https://orcid.org/0000-0002-7518-5797)
- Z. Song (ORCID: https://orcid.org/0000-0002-2128-8504)
- Guang Liang (ORCID: https://orcid.org/0000-0002-8278-849X)
- Wenyu Zhang (ORCID: https://orcid.org/0009-0001-1457-1707)
- Yan Li (ORCID: https://orcid.org/0000-0001-6021-1641)
- Zhi Xiao (ORCID: https://orcid.org/0009-0000-9300-3312)
- Qingmei Li (ORCID: https://orcid.org/0000-0003-2290-1080)
Institutions
- Zunyi Medical University (CN)
- Tongren Hospital (CN)
- Dongguan People’s Hospital (CN)
- Qujiang People's Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/cns.70560
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guizhou Science and Technology Department