Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study
Prolonged exposure to hyperglycemia is significantly associated with a lower average DTI-ALPS index, potentially playing a crucial role in the impairment of glymphatic function, especially among older adults. A well controlled blood glucose level may demonstrate a protective effect on glymphatic function, indicating better brain health.
Authors
- Shuohua Chen (ORCID: https://orcid.org/0000-0002-6274-7471)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0003-4123-3030)
- Han Lv (ORCID: https://orcid.org/0000-0001-9559-4777)
- Sihui Guo (ORCID: https://orcid.org/0000-0002-5511-2224)
- Jing Ping Sun (ORCID: https://orcid.org/0000-0003-2110-5189)
- Xiaoshuai Li (ORCID: https://orcid.org/0000-0002-9848-4597)
- Pengfei Zhao (ORCID: https://orcid.org/0000-0002-3287-914X)
- Zhenchang Wang (ORCID: https://orcid.org/0000-0001-5585-5805)
- Shouling Wu (ORCID: https://orcid.org/0000-0002-2921-7583)
- Yufan Zhang
- Ying Hui (ORCID: https://orcid.org/0009-0009-0534-210X)
- Jing Li (ORCID: https://orcid.org/0009-0003-6354-6975)
Institutions
- Capital Medical University (CN)
- Kailuan General Hospital (CN)
- Beijing Friendship Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.ibneur.2025.08.009
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Capital Medical University