Features of surgical treatment of hypertriglyceride–induced acute pancreatitis

Objective. To evaluate the effectiveness of surgical treatment of patients with hypertriglyceride–induced acute pancreatitis using plasmapheresis and prioritizing minimally invasive surgical interventions. Materials and methods. The results of treatment of 92 patients with hypertriglyceride–induced acute pancreatitis conducted between 2019 and 2024 were evaluated. The control group consisted of 35 (38.04%) patients, and the main group consisted of 57 (61.96%) patients who additionally underwent plasmapheresis. Results. After plasmapheresis, the average cholesterol, triglyceride, and atherogenic index levels were statistically significant (p < 0.05) lower than before treatment. In the control group, the decrease in these indicators was statistically insignificant (p˃ 0.05). With plasmapheresis, minimally invasive surgery became the final treatment for 31 (63.27%) of 49 patients, compared to 15 (53.57%) of 28 patients in the control group. All patients recovered. Uncontrolled arterial hypertension, morbid obesity, type II diabetes mellitus, and hypertriglyceridemia are reliable unfavorable prognostic risk factors in patients with hypertriglyceride–induced acute pancreatitis. Conclusions. In patients with hypertriglyceride–induced acute pancreatitis, early laboratory diagnosis and timely use of plasmapheresis allow for the correction of lipid metabolism parameters and increase the likelihood of a favorable course of the disease with the priority use of minimally invasive surgical interventions.