Fighting cardiac fibrosis using the chemomechanical method
Diffuse myocardial fibrosis affects disease severity and outcomes in multiple heart diseases. A recent study in NATURE has shown a chemomechanical method to regulate myocardial stromal cell states to suppress fibrosis in vitro and in vivo, which provides a proof-of-concept therapeutic strategy. This study reviews the proposed chemomechanical method and other recent biotechnologies to fight cardiac fibrosis.
Authors
- Yunlong Huo (ORCID: https://orcid.org/0000-0003-4121-3224)
Institutions
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Mechanobiology in Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.mbm.2025.100147
- Primary Topic
- Biomedical and Engineering Education
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China