Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery
Our study delineates spatially constrained mechanisms underlying migraine heterogeneity: MA arises from neuroimmune-epigenetic dysregulation, while MO is driven by vascular-metabolic perturbations. Key genes and pathways provide actionable targets for subtype-specific therapies. By bridging genetic architecture with spatial biology, we redefine migraine pathogenesis and precision intervention strategies.
Authors
- Lingbin He
- Ronghuai Shen
- Xianxi Huang (ORCID: https://orcid.org/0000-0001-5978-5031)
- Ling Xiao
- Xinyi Li (ORCID: https://orcid.org/0000-0002-8415-0385)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-9211-861X)
- Chao Yang (ORCID: https://orcid.org/0009-0005-6077-9153)
- Shuxu Wei
- Xiaojia Lu
- Suiqin Zhong (ORCID: https://orcid.org/0009-0007-1521-3569)
- Yan Quan (ORCID: https://orcid.org/0009-0000-6056-1414)
Institutions
- Fujian Medical University (CN)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s10194-025-02128-7
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88