Upregulated GDF‐15 in Ankylosing Spondylitis: Pathologic Ossification Promotion through Ligament Fibroblast Osteogenic Differentiation
This study revealed aberrant up-regulation of GDF-15 in an AS mouse model and osteogenic effect of GDF-15 in AS fibroblasts via the Wnt/β-catenin signaling pathway, which may be one of the mechanisms and therapeutic targets of new bone formation in AS.
Authors
- Junying Hua
- Yanting Zhong
- Jiaxiao Li (ORCID: https://orcid.org/0000-0002-7660-7859)
- Yang Cui
- Liao Cui
- GuoXian He
- Jinrong Xu
Institutions
- Guangdong Medical College (CN)
- First People's Hospital of Foshan (CN)
- Foshan Second People's Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/acr2.70075
- Citations
- 2
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.34