Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data
This target trial emulation study suggests that a liberal transfusion threshold may provide a modest survival benefit during the early course of VA-ECMO, but no benefit afterwards. Prospective studies are needed to confirm these findings, assess clinical adoption, and investigate underlying mechanism.
Authors
- James Walsham (ORCID: https://orcid.org/0000-0001-6852-4378)
- Danielle Austin (ORCID: https://orcid.org/0000-0003-1526-8555)
- Aidan Burrell (ORCID: https://orcid.org/0000-0001-8430-9678)
- Tri‐Long Nguyen (ORCID: https://orcid.org/0000-0002-6376-7212)
- Alexis Serra (ORCID: https://orcid.org/0000-0001-7366-1350)
- Nicolas J. Mueller (ORCID: https://orcid.org/0000-0002-1059-3191)
- Matthias Lubnow (ORCID: https://orcid.org/0000-0002-4402-1810)
- Phoebe McCracken
- Emma Martin
- Shirley Vallance (ORCID: https://orcid.org/0000-0001-8567-1783)
- Heidi Buhr
- Lê Thị Phương Thảo (ORCID: https://orcid.org/0000-0001-9661-6835)
- Meredith Young
- James Winearls (ORCID: https://orcid.org/0000-0002-0665-0034)
- Florian Geismann (ORCID: https://orcid.org/0000-0002-0952-0841)
- Kevin Rahn
- Chris Joyce (ORCID: https://orcid.org/0000-0001-7819-3373)
- David Gattas (ORCID: https://orcid.org/0000-0002-9282-7093)
- Jennifer Coles
- Carol Hodgson (ORCID: https://orcid.org/0000-0001-9002-2075)
- Jayne Sheldrake (ORCID: https://orcid.org/0000-0001-5805-7171)
- Hergen Buscher (ORCID: https://orcid.org/0000-0002-4531-6151)
- Meg Harward
- Jayshree Lavana
- Jason Meyer
- Mandy Tallott
- Claire Reynolds (ORCID: https://orcid.org/0000-0003-3452-0832)
- Judith Mckay
- James P. McCullough (ORCID: https://orcid.org/0000-0002-7292-2237)
- Andrew Retter (ORCID: https://orcid.org/0000-0001-7373-6404)
- Maimoonbe Gough
- Ruan Vlok (ORCID: https://orcid.org/0000-0002-6729-7772)
- Antonio Arcadipane
- Matthieu Schmidt (ORCID: https://orcid.org/0000-0002-2931-4412)
- Maithri Siriwardena (ORCID: https://orcid.org/0000-0001-9498-5573)
- Rachel Bushell
- Richard Totaro (ORCID: https://orcid.org/0000-0002-1606-5197)
- Gennaro Martucci (ORCID: https://orcid.org/0000-0001-8443-2414)
- Georg Trummer
- Maree Houbert
- Jan‐Steffen Pooth (ORCID: https://orcid.org/0000-0001-6882-2009)
- Bentley J. Fulcher (ORCID: https://orcid.org/0000-0002-5289-032X)
- Peter McCanny
- Johannes Gratz (ORCID: https://orcid.org/0000-0001-8717-0544)
- Melchior Gautier
- Priya Nair (ORCID: https://orcid.org/0000-0002-9771-7619)
- Sally Newman
- Julie Pitman
- Annalie Jones (ORCID: https://orcid.org/0009-0001-0553-5886)
- John F. Fraser
- Koji Takeda
- Kiran Shekar
- Daniel Brodie
- Jennene Miller
- Vincent Pellegrino
- Dawn Lockwood
- Anders Aneman
- Ruaidhri Carey
- Dee Figures
- Raymond Marteene
Institutions
- University of Copenhagen (DK)
- The University of Sydney (AU)
- Johns Hopkins University (US)
- The University of Queensland (AU)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Royal Prince Alfred Hospital (AU)
- Johns Hopkins Medicine (US)
- Royal North Shore Hospital (AU)
- Gold Coast Hospital (AU)
- Liverpool Hospital (AU)
- University Medical Center Freiburg (DE)
- Princess Alexandra Hospital (AU)
- The Alfred Hospital (AU)
- University Hospital Regensburg (DE)
- Sorbonne Université (FR)
- St Vincent's Hospital Sydney (AU)
- Presbyterian Hospital (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- St Vincent’s Private Hospital Sydney (AU)
- Monash Health (AU)
- Prince Charles Hospital (AU)
- South Western Sydney Local Health District (AU)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
- Franklin University (US)
- Monash University (AU)
- New York University (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Critical Care
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s13054-025-05606-1
- Citations
- 4
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- Intensive Care Society