Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data

This target trial emulation study suggests that a liberal transfusion threshold may provide a modest survival benefit during the early course of VA-ECMO, but no benefit afterwards. Prospective studies are needed to confirm these findings, assess clinical adoption, and investigate underlying mechanism.

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Publication Details

Journal
Critical Care
Published
2025-08-18
DOI
https://doi.org/10.1186/s13054-025-05606-1
Citations
4
Primary Topic
Mechanical Circulatory Support Devices
Type
article
Field-Weighted Citation Impact
2.70

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article

Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data

James Walsham, Danielle Austin, Aidan Burrell, Tri‐Long Nguyen et al.
4 citations
Critical Care
Mechanical Circulatory Support Devices
2.70
article

Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data

James Walsham, Danielle Austin, Aidan Burrell, Tri‐Long Nguyen, Alexis Serra, Nicolas J. Mueller, Matthias Lubnow, Phoebe McCracken, Emma Martin, Shirley Vallance, Heidi Buhr, Lê Thị Phương Thảo, Meredith Young, James Winearls, Florian Geismann, Kevin Rahn, Chris Joyce, David Gattas, Jennifer Coles, Carol Hodgson, Jayne Sheldrake, Hergen Buscher, Meg Harward, Jayshree Lavana, Jason Meyer, Mandy Tallott, Claire Reynolds, Judith Mckay, James P. McCullough, Andrew Retter, Maimoonbe Gough, Ruan Vlok, Antonio Arcadipane, Matthieu Schmidt, Maithri Siriwardena, Rachel Bushell, Richard Totaro, Gennaro Martucci, Georg Trummer, Maree Houbert, Jan‐Steffen Pooth, Bentley J. Fulcher, Peter McCanny, Johannes Gratz, Melchior Gautier, Priya Nair, Sally Newman, Julie Pitman, Annalie Jones, John F. Fraser, Koji Takeda, Kiran Shekar, Daniel Brodie, Jennene Miller, Vincent Pellegrino, Dawn Lockwood, Anders Aneman, Ruaidhri Carey, Dee Figures, Raymond Marteene
article en
4 citations

Abstract

This target trial emulation study suggests that a liberal transfusion threshold may provide a modest survival benefit during the early course of VA-ECMO, but no benefit afterwards. Prospective studies are needed to confirm these findings, assess clinical adoption, and investigate underlying mechanism.

Critical CareVol. 29(1)
University of Copenhagen (DK), The University of Sydney (AU), Johns Hopkins University (US), The University of Queensland (AU), Guy's and St Thomas' NHS Foundation Trust (GB), Royal Prince Alfred Hospital (AU), Johns Hopkins Medicine (US), Royal North Shore Hospital (AU), Gold Coast Hospital (AU), Liverpool Hospital (AU), University Medical Center Freiburg (DE), Princess Alexandra Hospital (AU), The Alfred Hospital (AU), University Hospital Regensburg (DE), Sorbonne Université (FR), St Vincent's Hospital Sydney (AU), Presbyterian Hospital (US), Assistance Publique – Hôpitaux de Paris (FR), St Vincent’s Private Hospital Sydney (AU), Monash Health (AU), Prince Charles Hospital (AU), South Western Sydney Local Health District (AU), Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT), Franklin University (US), Monash University (AU), New York University (US), Medical University of Vienna (AT)
Intensive Care Society
Openalex Percentile: Top 10%
Mechanical Circulatory Support Devices
2.70
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