A Novel Monoterpenoid Derivative Isolated from Chloranthus serratus Roots with Anti-inflammatory Activity

Eight compounds were isolated from the 95% ethanol extract of Chloranthus serratus roots, including two monoterpenoid derivatives (1, 2), one pimarane-type diterpenoid (3), and five labdane-type diterpenoids (4-8).Compound 1 was identified as a previously undescribed camphene derivative, while compound 3 was a new natural product.Their structures and relative configurations were elucidated using HR-MS, NMR and ECD calculations.Compounds 1, 2, 5 significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with IC50 values of 17.471.24,14.921.17,and 30.481.48 M, respectively.