Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte function
Bioinformatics revealed differences and possible mechanisms of action of exosomes derived from pluripotent hiPSCs, multipotent hADSCs, and multipotent hBMSCs, and these exosomes effectively suppressed cell senescence and promoted normal functional extracellular matrix formation in hACs. Further investigations of the different functions of exosomes from pluripotent-hiPSCs other than those from multipotent-hMSCs are needed.
Authors
- Chung‐Hwan Chen (ORCID: https://orcid.org/0000-0001-8941-4792)
- Mei‐Ling Ho (ORCID: https://orcid.org/0000-0001-8064-8488)
- Che-Wei Wu (ORCID: https://orcid.org/0000-0001-6464-8525)
- Shun‐Cheng Wu (ORCID: https://orcid.org/0000-0003-4219-3413)
- Shu‐Chun Chuang (ORCID: https://orcid.org/0000-0002-1190-5687)
- Jhen-Wei Chen
- Yu-Hsuan Chung
- Yin‐Chih Fu
- Ching‐Wen Liu
- Ling-Hua Chang
- Je-Ken Chang
- Yi-Shan Lin
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- National Pingtung University of Science and Technology (TW)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1302/2046-3758.148.bjr-2024-0267.r4
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22