Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study
We observed an association between LDL levels, but not statin treatment, and incident dementia/CD. Although causality cannot be determined by our study, the results are in line with multiple randomised controlled trials. However, to understand the long-term effects of lipid levels and statin treatment on dementia/CD, studies of longer follow-up are still needed.
Authors
- Miriam Pikkemaat (ORCID: https://orcid.org/0000-0002-9808-207X)
- Mark Woodward (ORCID: https://orcid.org/0000-0001-9800-5296)
- Katie Harris (ORCID: https://orcid.org/0000-0003-2444-2869)
- Peder af Geijerstam (ORCID: https://orcid.org/0000-0001-6038-5131)
- John Chalmers (ORCID: https://orcid.org/0000-0002-9931-0580)
- Giuseppe Mancia (ORCID: https://orcid.org/0000-0003-0942-3176)
- Michel Marre (ORCID: https://orcid.org/0000-0002-3071-1837)
- Ruth Peters (ORCID: https://orcid.org/0000-0003-0148-3617)
Institutions
- Linköping University (SE)
- Inserm (FR)
- Malmö University (SE)
- The George Institute for Global Health (GB)
- Lund University (SE)
- Université Paris Cité (FR)
- UNSW Sydney (AU)
- Institut Necker Enfants Malades (FR)
- The George Institute for Global Health (AU)
- Skåne University Hospital (SE)
- Clinique Ambroise Paré (FR)
- Imperial College London (GB)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12933-025-02894-3
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Linköpings Universitet