Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes
The LL genotype of the HMOX1 GTn repeat and the AA genotype of -413A/T SNP were associated with ischemic cardiac complications and all-cause mortality in men, but not in women. Thus, the HMOX1 genotype may influence the development of cardiovascular complications in individuals with T1D in a sex-dependent manner.
Authors
- Ilkka Tikkanen (ORCID: https://orcid.org/0000-0001-8519-9722)
- Päivi Lakkisto (ORCID: https://orcid.org/0000-0001-9935-6573)
- Riikka Kosonen
- Heidi K. Tikkanen
- Mika Laine (ORCID: https://orcid.org/0000-0002-6906-8877)
- Niina Sandholm (ORCID: https://orcid.org/0000-0003-4322-6942)
- Heli Segersvärd (ORCID: https://orcid.org/0000-0002-2901-4006)
- Per-Henrik Groop
- Valma Harjutsalo
Institutions
- University of Helsinki (FI)
- Baker Heart and Diabetes Institute (AU)
- Helsinki University Hospital (FI)
- Minerva Foundation (FI)
- Folkhälsans Forskningscentrum (FI)
- Monash University (AU)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12933-025-02895-2
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Cardiovascular Research
- Helsingin Yliopisto
- Wilhelm och Else Stockmanns Stiftelse
- Aarne Koskelon Säätiö
- Finska Läkaresällskapet
- Folkhälsanin Tutkimussäätiö
- Novo Nordisk
- Samfundet Folkhälsan
- Sydäntutkimussäätiö
- Fondation pour la Médecine de Laboratoire
- Novo Nordisk Fonden
- Diabetestutkimussäätiö