Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History
Serum inflammatory mediators and salivary microbiome complement asthma attacks history for predicting future attacks. These results highlight the imperative for continued investigation into oral microbiota and its interaction with the immune system.
Authors
- Peter Sterk (ORCID: https://orcid.org/0000-0003-1668-7778)
- Susanne Harner (ORCID: https://orcid.org/0000-0001-6733-5823)
- Jonathan Thorsen (ORCID: https://orcid.org/0000-0003-0200-0461)
- Klaus Bønnelykke (ORCID: https://orcid.org/0000-0003-2003-1018)
- Corinna Bang (ORCID: https://orcid.org/0000-0001-6814-6151)
- Simone Hashimoto (ORCID: https://orcid.org/0000-0001-8995-3817)
- Stephen James Fowler (ORCID: https://orcid.org/0000-0002-4524-1663)
- Louise Fleming (ORCID: https://orcid.org/0000-0002-7268-7433)
- Bo Chawes (ORCID: https://orcid.org/0000-0001-6846-6243)
- Suzanne W. J. Terheggen‐Lagro (ORCID: https://orcid.org/0000-0002-3305-3745)
- Mahmoud I. Abdel‐Aziz (ORCID: https://orcid.org/0000-0001-9263-7137)
- Mario Gorenjak (ORCID: https://orcid.org/0000-0003-4208-9683)
- Uroš Potočnik (ORCID: https://orcid.org/0000-0003-1624-9428)
- Anke H. Maitland‐van der Zee (ORCID: https://orcid.org/0000-0002-0414-3442)
- Olaia Sardón‐Prado (ORCID: https://orcid.org/0000-0002-1567-9824)
- Anne H. Neerincx (ORCID: https://orcid.org/0000-0002-4533-486X)
- Aruna T. Bansal (ORCID: https://orcid.org/0000-0002-7262-6534)
- Sven‐Erik Dahlén (ORCID: https://orcid.org/0000-0002-4993-4002)
- Susanne J. H. Vijverberg (ORCID: https://orcid.org/0000-0002-4579-4081)
- Antoaneta A. Toncheva (ORCID: https://orcid.org/0000-0001-5019-5174)
- Søren Johannes Sørensen (ORCID: https://orcid.org/0000-0001-6227-9906)
- Dominick Shaw (ORCID: https://orcid.org/0000-0003-4106-8469)
- Gunilla Hedlin (ORCID: https://orcid.org/0000-0001-7737-6506)
- Jakob Stokholm (ORCID: https://orcid.org/0000-0003-4989-9769)
- Paula Corcuera (ORCID: https://orcid.org/0000-0001-8661-7033)
- Kian Fan Chung (ORCID: https://orcid.org/0000-0001-7101-1426)
- Heike Buntrock‐Döpke
- Paul Brinkman (ORCID: https://orcid.org/0000-0003-4546-8478)
- Alexander Kiefer (ORCID: https://orcid.org/0000-0003-2492-8850)
- Ratko Djukanović (ORCID: https://orcid.org/0000-0001-6039-5612)
- Florian Singer (ORCID: https://orcid.org/0000-0003-3471-5664)
- René Lutter (ORCID: https://orcid.org/0000-0002-6243-9911)
- JanWillem Duitman (ORCID: https://orcid.org/0000-0003-4254-3380)
- Aletta D. Kraneveld (ORCID: https://orcid.org/0000-0001-9819-383X)
- Maria Pino‐Yanes (ORCID: https://orcid.org/0000-0003-0332-437X)
- Susanne Brandstetter (ORCID: https://orcid.org/0000-0002-7021-8895)
- Charles Auffray (ORCID: https://orcid.org/0000-0003-2226-7411)
- Nazanin Zounemat Kermani (ORCID: https://orcid.org/0000-0003-2479-3861)
- Barbara Smids
- Urs Frey (ORCID: https://orcid.org/0000-0003-3773-2822)
- Clare Murray (ORCID: https://orcid.org/0000-0002-8961-8055)
- Shahriyar Shahbazi Khamas (ORCID: https://orcid.org/0000-0003-3252-600X)
- Andrew Bush (ORCID: https://orcid.org/0000-0001-6756-9822)
- Ian Michael Adcock (ORCID: https://orcid.org/0000-0003-2101-8843)
- Christine Wolff (ORCID: https://orcid.org/0000-0002-7694-4476)
- Michael Kabesch (ORCID: https://orcid.org/0000-0003-0697-1871)
- Graham Roberts (ORCID: https://orcid.org/0000-0003-2252-1248)
- Jelle M. Blankestijn (ORCID: https://orcid.org/0009-0006-2047-0888)
- Jon R. Konradsen (ORCID: https://orcid.org/0000-0001-7745-8624)
- André Franke (ORCID: https://orcid.org/0000-0003-1530-5811)
- Nadja Hawwa Vissing (ORCID: https://orcid.org/0000-0003-0662-2727)
- Björn Nordlund (ORCID: https://orcid.org/0000-0001-9888-1659)
- Eric G. Haarman (ORCID: https://orcid.org/0000-0003-1303-1423)
- Leyre López‐Fernández
- Tamara Dekker
- Nariman K. A. Metwally
- Ana R. Sousa
- Fleur Sondaal
- Parastoo Kheirolldein
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Bern (CH)
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- Karolinska University Hospital (SE)
- Inserm (FR)
- Universidad de La Laguna (ES)
- St. John's College of Nursing (US)
- University of the Basque Country (ES)
- University of Basel (CH)
- GlaxoSmithKline (United Kingdom) (GB)
- Utrecht University (NL)
- Medical University of Graz (AT)
- Manchester Academic Health Science Centre (GB)
- University Hospital of Bern (CH)
- Instituto de Salud Carlos III (ES)
- Harefield Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- University Hospital Regensburg (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Maribor (SI)
- University College Copenhagen (DK)
- Emma Kinderziekenhuis (NL)
- Royal Brompton Hospital (GB)
- Biogipuzkoa Health Research Institute (ES)
- Amsterdam Neuroscience (NL)
- NIHR Southampton Biomedical Research Centre (GB)
- Copenhagen Prospective Studies on Asthma in Childhood (DK)
- University Children’s Hospital Basel (CH)
- University Clinical Centre Maribor (SI)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Centre International de Recherche en Infectiologie (FR)
- NIHR Leicester Biomedical Research Centre (GB)
- European Institute for Systems Biology and Medicine
- Imperial College London (GB)
- Amsterdam University of Applied Sciences (NL)
- IT University of Copenhagen (DK)
- University of Amsterdam (NL)
Publication Details
- Journal
- Allergy
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1111/all.70004
- Citations
- 3
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Chiesi Farmaceutici
- Universität Basel
- University of Bern
- Regeneron Pharmaceuticals
- University Hospital Southampton NHS Foundation Trust
- Vertex Pharmaceuticals
- European Federation of Pharmaceutical Industries and Associations
- Universidad de La Laguna
- Inselspital, Universitätsspital Bern
- Celltrion
- Amsterdam University Medical Centers
- GlaxoSmithKline España
- National Institute for Health and Care Research
- Asthma and Lung UK
- University of Leicester
- University of Southampton
- Imperial College London
- European Commission
- Institut National de la Santé et de la Recherche Médicale
- ZonMw
- Universiteit van Amsterdam
- Universiteit Utrecht
- Bundesministerium für Bildung und Forschung
- Gentofte Hospital
- Euskal Herriko Unibertsitatea
- Karolinska Institutet
- Novo Nordisk
- Javna Agencija za Raziskovalno Dejavnost RS
- Stichting Astma Bestrijding
- Stockholms Läns Landsting
- Centre National de la Recherche Scientifique
- Universität Regensburg
- Ministrstvo za Izobraževanje, Znanost in Šport
- Université Claude Bernard Lyon 1
- Karl-Franzens-Universität Graz
- Univerza v Mariboru
- Medizinische Universität Graz
- European Academy of Allergy and Clinical Immunology
- Univerzitetni Klinični Center Maribor
- Directorate for Biological Sciences
- Novartis Pharma
- Seventh Framework Programme
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Instituto de Salud Carlos III
- Institute of Infection and Immunity
- FP7 Health