EXPRESS: CB2 receptor agonist AM1241 regulating the polarization of microglia reduces morphine tolerance through IL-4/STAT6 pathway
The polarization of microglia in the direction of M1 caused morphine tolerance, AM1241 increased the IL-4 mRNA and induced the phosphorylation protein of STAT6 to reduce the tolerance, and AM1241 induced microglia to polarization in the direction of M2. AM1241 regulated microglia polarization through IL-4/STAT6 pathway, thereby reducing tolerance.
Authors
- Chuhua Yang
- Guonian Wang (ORCID: https://orcid.org/0000-0002-5525-9939)
- Qingling Kong
- Yuanyuan Zhang (ORCID: https://orcid.org/0009-0000-8822-2406)
- Mingyue Zhang
- Di Cui (ORCID: https://orcid.org/0009-0007-9686-3001)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Hanzhong People's Hospital (CN)
- Hanzhong Central Hospital (CN)
Publication Details
- Journal
- Molecular Pain
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1177/17448069251374281
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00