Oxidative stress-related biomarkers in thyroid eye disease: evidence from bioinformatics analysis and experimental validation
To the best of our knowledge, this study is the first to identify three oxidative stress-related genes/proteins as potential biomarkers for TED through bioinformatic analysis of multi-omics data followed by immunohistochemical validation, providing new insights into their roles in the pathogenesis of the disease. These biomarkers could aid in early screening and risk assessment for TED.
Authors
- Alex Y. Huang (ORCID: https://orcid.org/0000-0002-5701-4521)
- Thomas Efferth (ORCID: https://orcid.org/0000-0002-2637-1681)
- Sijie Fang (ORCID: https://orcid.org/0000-0003-1423-4820)
- Cheng Song (ORCID: https://orcid.org/0000-0001-6274-330X)
- Genfeng Yu
- Yuanping Hai (ORCID: https://orcid.org/0000-0003-1709-6996)
- Zhitao Liu (ORCID: https://orcid.org/0000-0002-2150-5548)
- Yi Wang (ORCID: https://orcid.org/0000-0001-9921-0304)
- Jie Shen (ORCID: https://orcid.org/0000-0001-6952-9541)
- Lan Liu (ORCID: https://orcid.org/0000-0001-7642-6479)
- Dongxiao Li (ORCID: https://orcid.org/0000-0001-9195-7753)
- Yan Zhu (ORCID: https://orcid.org/0000-0003-1983-8690)
- Qintao Ma
- Duan Yongbo
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Johannes Gutenberg University Mainz (DE)
- Peking University (CN)
- Shanghai Ninth People's Hospital (CN)
- The First People's Hospital of Shunde (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1635712
- Citations
- 2
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- Hunan University
- Basic and Applied Basic Research Foundation of Guangdong Province