Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy
We were able to culture MTC organoids that resemble the original tissue in gene expression, protein expression, and functionality. However, international, multi-center studies are required to meet the standards for future clinical applications.
Authors
- Uilke Brouwer
- Schelto Kruijff (ORCID: https://orcid.org/0000-0002-5151-7320)
- Robert P. Coppes (ORCID: https://orcid.org/0000-0001-5503-1064)
- Liesbeth Jansen (ORCID: https://orcid.org/0000-0002-5363-132X)
- Inês F. Antunes (ORCID: https://orcid.org/0000-0002-8003-5291)
- Eline C. Jager (ORCID: https://orcid.org/0000-0001-8296-6703)
- Wouter T. Zandee (ORCID: https://orcid.org/0000-0001-7979-6969)
- Thera P. Links (ORCID: https://orcid.org/0000-0001-5327-1718)
- Adrienne H. Brouwers (ORCID: https://orcid.org/0000-0003-2698-1516)
- Rufina Maturi (ORCID: https://orcid.org/0009-0006-0493-3651)
- Luc Sondorp (ORCID: https://orcid.org/0009-0003-3798-9393)
- Bettien M. van Hemel
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Karolinska Institutet (SE)
- University of Naples Federico II (IT)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1530/etj-24-0405
- Citations
- 2
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Stichting De Cock-Hadders
- Universitair Medisch Centrum Groningen