In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage
Our data suggest that SARS-CoV-2 infection alone does not cause sustained proteomic alterations in most children. However, MIS-C is associated with a distinct inflammatory and vascular injury signature. Several candidate diagnostic biomarkers for MIS-C were identified and validated in silico, offering promising avenues for future diagnostic and therapeutic strategies.
Authors
- Claire Tonry (ORCID: https://orcid.org/0000-0002-5830-3472)
- Thomas Waterfield (ORCID: https://orcid.org/0000-0001-9452-7716)
- Chris Watson (ORCID: https://orcid.org/0000-0001-8749-0732)
- Cathal Roarty (ORCID: https://orcid.org/0000-0002-4689-1975)
- Claire McGinn (ORCID: https://orcid.org/0000-0002-5095-7084)
- Sharon Christie
Institutions
- Queen's University Belfast (GB)
- Royal Belfast Hospital for Sick Children (GB)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12967-025-06826-3
- Citations
- 2
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Queen's University Belfast
- Public Health Agency
- Queen's University
- Hospital for Sick Children
- Northern Ireland Chest Heart and Stroke