494. THE POPULATION BASED RISK OF OBSTRUCTIVE SLEEP APNEA AND PSYCHIATRIC DISORDER

Abstract Background Obstructive Sleep Apnea (OSA) is associated with a range of psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia, likely due to the physiological disruptions caused by intermittent hypoxia and sleep fragmentation. Aims & Objectives To assess the risk differences for psychiatric disorders in patients with OSA compared to those without OSA. Method Design, setting, and participants A retrospective cohort study using de-identified electronic health records from the TriNetX US Network, including adult patients aged 18-65 who had at least two medical examinations between 2016 and 2023. After propensity score matching, 360,708 patients were included in both OSA and non-OSA cohorts. Exposures Diagnosis of OSA, as recorded in medical records with ICD-10 code G47.33. Main outcomes and neasyres Incidence of psychiatric disorders, specifically schizophrenia, bipolar disorder, depressive disorders, and anxiety-related diseases, tracked over an 8-year period. Results OSA patients showed higher cumulative probabilities for psychiatric disorders at 1, 3, and 8 years compared to non-OSA patients. Hazard ratios indicated significantly elevated risks for depressive disorders (HR: 1.913), anxiety-related diseases (HR: 1.663), and bipolar disorder (HR: 1.885). Minimal risk difference was observed for schizophrenia. Discussion & Conclusions This study highlights the heightened risk of psychiatric disorders in OSA patients, suggesting that comprehensive management should incorporate mental health assessments to improve overall outcomes in this population.