405. AN ELECTROENCEPHALOGRAPHY CONNECTOME PREDICTIVE MODEL OF CRAVING FOR METHAMPHETAMINE

Abstract Background Methamphetamine use disorder (MUD) is characterized by prominent psychological craving and its relapsing nature. Previous studies have linked trait impulsivity and abstinence duration to drug use, but the neural substrates of drug cue-induced craving and its relationship with these traits remain unclear in MUD. Aims & Objectives The primary aim of this study was to elucidate the neural substrates underlying methamphetamine cue-induced craving in individuals with MUD. Specifically, we sought to identify a unified neural signature for craving within resting-state high-density electroencephalography (HD resting EEG) recordings. Method We acquired high-density resting-state electroencephalography (EEG) after participants watched a five-minute video demonstrating methamphetamine use. Combining precise source imaging to reconstruct brain activities with connectome predictive modeling (CPM), we built a craving-specific network within beta band activity from two independent MUD cohorts (N=144 for model development and N=47 for validation). Results This network reveals a unified neural signature for craving in MUD, spanning multiple brain networks including the medial prefrontal, frontal parietal, and subcortical networks. Our findings underscored the mediating role of this craving connectome profile in modulating the relationship between abstinence duration and craving intensity. Moreover, trait impulsivity mediated the relationship between the EEG-derived craving connectome and cue-induced craving. Discussion & Conclusions This study presents a novel predictive model that utilizes sourced connectivity from high-density EEG of resting-state recording to successfully predict methamphetamine craving in abstinent individuals with MUD. These results shed light on the cognitive organization involved in craving, involving cognitive control, attention, and reward reactivity. A comprehensive analysis reveals EEG data’s capacity to decipher craving’s complex dynamics, facilitating improved understanding and targeted treatments for substance use disorders.