346. LIPID CORE-ENCAPSULATED CANNABIDIOL CAUSES ANXIOLYTIC- AND PANICOLYTIC-LIKE EFFECTS ON DEFENSIVE BEHAVIOR ELICITED IN MICE BY <i>BOTHROPS JARARACA</i> LANCEHEAD PIT VIPERS

Abstract Background The burgeoning interest in cannabinoid-based therapies for mental disorders motivates research into their efficacy. Aims &amp; Objectives This study aimed to investigate the acute effects of nanoencapsulated cannabidiol (CBD) on panic attack-like defensive responses elicited in mice by the venomous snake Bothrops jararaca in polygonal arenas validated as a panic attack experimental model. Method Mice were habituated in the enriched polygonal arena during three days and treated with either CBD or nanostructured CBD at different doses before snake confrontation. Results Mice displayed antipredatory behaviours when confronted by snakes compared to a non-threatening stimulus, emphasising the validity of the panic model. Both non-encapsulated and nanoencapsulated CBD, in this latter formulation particularly at lower doses, attenuated panic-like responses, including defensive attention, flat back approach, and escape behaviours to safe places. Discussion &amp; Conclusions These findings suggest that nanoencapsulated CBD holds promise as an effective treatment for anxiety disorders, potentially mitigating adverse effects associated with cannabinoid therapy.