702. INNOVATIVE PERSPECTIVES IN NEUROPSYCHOPHARMACOLOGY: INSIGHTS FROM INDONESIA, NEWZEALAND AND AUSTRALIA

Abstract Background Electroconvulsive therapy (ECT) is known to be effective for treating severe mood and psychotic disorders in adults, especially when medications do not work well. However, its use in adolescents is still uncommon because of concerns about possible effects on memory and thinking. Aims & Objectives This study aiming to describe clinical outcomes in adolescent patients diagnosed with first-episode psychotic spectrum disorders who received combined electroconvulsive therapy (ECT) and antipsychotic pharmacotherapy. Method This study a retrospective case series design. The cases were collected from Psychiatric Hospital over a period of Januari - April 2025. Results All four adolescent patients showed significant improvement in aggression and psychotic symptoms, with reduced PANSS-EC scores. Cognitive function, assessed with MoCA-Ina, also improved in all cases. The combination of ECT and antipsychotics was well tolerated, with no major side effects reported. All patients completed the full course of treatment by the Positive and Negative Syndrome Scale – Excited Component (PANSS-EC). Discussion & Conclusions This case series suggests that combining ECT with antipsychotics can be a safe and effective treatment for adolescents with first-episode psychotic spectrum disorders, especially when rapid symptom control is needed. With proper safety measures and ethical oversight, ECT should be considered a treatment option in selected cases. Further studies with larger samples and long-term follow-up are needed to better establish the safety, efficacy, and guidelines for ECT use in this population.