Mechanism of action behind the pain-relief effects of extracellular vesicles in microfragmented adipose tissue: an in vitro and in vivo study
This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and adhered to all relevant national and institutional ethical guidelines for research involving human participants. Approval for the study was obtained from the Ethics Committee of Marche Region, protocol n. 154/2021. All participants provided written informed consent before enrollment in the study. They were informed about the study's purpose, procedures, potential risks, and their right to withdraw at any time without consequences. Informed Patient Consent Statement: Informed consent was obtained from all individual participants included in the study, following the guidelines of the Human Research Approval Committee protocol number 2/2019.
Authors
- Alfredo Ronca (ORCID: https://orcid.org/0000-0002-6658-004X)
- Letizia Senesi (ORCID: https://orcid.org/0000-0001-6635-4707)
- Luca Lovatti (ORCID: https://orcid.org/0000-0001-7696-9297)
- Ali Mobasheri (ORCID: https://orcid.org/0000-0001-6261-1286)
- Ilaria Zanolla (ORCID: https://orcid.org/0000-0002-7395-787X)
- Barbara Zavan (ORCID: https://orcid.org/0000-0002-4779-4456)
- Mario Fordellone (ORCID: https://orcid.org/0000-0003-0790-892X)
- Ugo D’Amora (ORCID: https://orcid.org/0000-0002-6142-059X)
- Paolo Pinton (ORCID: https://orcid.org/0000-0001-7108-6508)
- Massimo Bonora (ORCID: https://orcid.org/0000-0002-5752-3318)
- Michele Riccio (ORCID: https://orcid.org/0000-0001-5554-4759)
- Eduardo Sommella (ORCID: https://orcid.org/0000-0001-8654-6431)
- Francesco De Francesco (ORCID: https://orcid.org/0000-0003-2977-7828)
- Letizia Ferroni (ORCID: https://orcid.org/0000-0002-5457-0338)
- Elena Tremoli (ORCID: https://orcid.org/0000-0003-3426-6424)
- Ilenia Pia Cappucci
- Lucia Sileo
- Maria Pia Cavaleri
- Noemi De Cesare
- Anna Maria Monachino
Institutions
- Marche Polytechnic University (IT)
- University of Salerno (IT)
- University of Liège (BE)
- University of Ferrara (IT)
- Maria Cecilia Hospital (IT)
- State Research Institute Centre for Innovative Medicine (LT)
- University of Campania "Luigi Vanvitelli" (IT)
- National Research Council (IT)
- Institute of Polymers, Composites and Biomaterials (IT)
- University of Oulu (FI)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12967-025-06930-4
- Citations
- 1
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.72