Gastric microbiota transplantation enhanced the eradication of refractory <i>Helicobacter pylori</i> infection by modulating the gastric microbiota: a pilot study

Dysbiosis of the gastric microecology is implicated in various gastric diseases, with <i>Helicobacter pylori (H. pylori)</i> infection serving as a pivotal factor influencing the gastric microecological balance and vice versa. We investigated the novel effects of gastric microbiota transplantation (GMT) on gastric microecology and the potential of this treatment to enhance <i>H. pylori</i> eradication. GMT significantly enhanced the eradication rate of refractory <i>H. pylori</i> infection and improved symptoms in patients with <i>H. pylori</i>-positive atrophic gastritis. GMT demonstrated improvements in the cure rate of refractory <i>H. pylori</i> infection, potentially offering a new clinical treatment approach. This finding provides new insights and a potential therapeutic direction for treating dysbiosis related chronic gastric diseases.