Addition of Intramuscular Epinephrine to Standard of Care by Paramedics to Decrease Time-to-Initial Epinephrine Dose in Pediatric Out-of-Hospital Cardiac Arrest: A Simulation Trial
This is the first study to demonstrate that IM epinephrine by autoinjector is feasible in a simulated POHCA scenario and confers a significant advantage in time to initial dose of epinephrine. This study will inform future human trials of IM epinephrine for POHCA.
Authors
- Janice A. Tijssen (ORCID: https://orcid.org/0000-0003-0630-6169)
- Katie McKenzie
- Matthew Davis (ORCID: https://orcid.org/0000-0001-5125-1561)
- Facundo García‐Bournissen (ORCID: https://orcid.org/0000-0002-8732-247X)
- Jay Loosley
- Saoirse Cameron (ORCID: https://orcid.org/0000-0002-9295-2636)
- Michael R. Miller (ORCID: https://orcid.org/0000-0002-8891-9032)
- Maysaa Assaf
- Katelyn Gray
Institutions
- Western University (CA)
- University of Toronto (CA)
- London Health Sciences Centre (CA)
- Toronto General Hospital (CA)
- Middlesex London Health Unit (CA)
- Children’s Health Research Institute (CA)
Publication Details
- Journal
- Prehospital Emergency Care
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1080/10903127.2025.2536223
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00