Cytotoxicity of Bulk-Fill Composites on Stem Cells from Human Exfoliated Deciduous Teeth—An In Vitro Study

Bulk-fill composites and conventional compomer tested exhibit comparable and significant cytotoxic effects on stem cells from human exfoliated primary teeth pulp. While these materials offer clinical advantages in pediatric dentistry due to ease and speed of application, their use underscores the dilemma of balancing operative efficiency with biological safety, and their cytotoxic profiles should be taken into consideration prior to application.

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Publication Details

Journal
Materials
Published
2025-08-18
DOI
https://doi.org/10.3390/ma18163863
Primary Topic
Dental materials and restorations
Type
article
Field-Weighted Citation Impact
0.00

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article

Cytotoxicity of Bulk-Fill Composites on Stem Cells from Human Exfoliated Deciduous Teeth—An In Vitro Study

Krasimir Hristov, Ralitsa Bogovska-Gigova, Nikolay Ishkitiev, Marina Miteva
Materials
Dental materials and restorations
article

Cytotoxicity of Bulk-Fill Composites on Stem Cells from Human Exfoliated Deciduous Teeth—An In Vitro Study

Krasimir Hristov, Ralitsa Bogovska-Gigova, Nikolay Ishkitiev, Marina Miteva
article en

Abstract

Bulk-fill composites and conventional compomer tested exhibit comparable and significant cytotoxic effects on stem cells from human exfoliated primary teeth pulp. While these materials offer clinical advantages in pediatric dentistry due to ease and speed of application, their use underscores the dilemma of balancing operative efficiency with biological safety, and their cytotoxic profiles should be taken into consideration prior to application.

MaterialsVol. 18(16)
Medical University of Sofia (BG)
Medical University Sofia
Openalex Percentile: Top 78%
Dental materials and restorations
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