Controversial ‘arsenic life’ paper retracted from Science

After almost 15 years, the influential scholarly journal Science has retracted a controversial paper about the discovery of a microbe able to use arsenic instead of phosphorous in its biochemical processes (Science 2010, DOI: 10.1126/science.1197258).In the retraction notice, H. Holden Thorp, Science’s editor in chief since 2019, states that the paper is being retracted on the basis that the “reported experiments do not support its key conclusions” but not because of any deliberate fraud or misconduct.The retraction is accompanied by a letter from the authors disagreeing with the decision, stating, “While our work could have been written and discussed more carefully, we stand by the data as reported.”In the original paper, the authors describe an extremophile microbe called GFAJ-1 that they believe has the ability to weave arsenic into its proteins and nucleic acids to compensate for a lack of phosphorus. Confirming that arsenic can be incorporated into DNA has the potential to expand the chemical understanding of life on Earth—and beyond, an aspect that NASA and the journal initially played up.The paper immediately garnered harsh criticism from the scientific community over the researchers’ methods and conclusions. In 2012, Science published two papers from independent teams who were unable to replicate the original paper’s results..The current consensus is that although GFAJ-1 is unusually good at growing in high concentrations of toxic arsenic, sufficient evidence hasn’t been found that it actually incorporates arsenic into its DNA, and the bacterium likely survives by scavenging trace phosphorus from its surroundings. The authors say