Secreted lumican from the tumor microenvironment potentiates HCC stemness and progression
Secreted lumican promotes HCC self-renewal, tumor initiation, and progression by activating the AKT/GSK3β/β-catenin signaling cascade. Targeting secreted lumican is a potential therapeutic strategy for HCC.
Authors
- Tan To Cheung (ORCID: https://orcid.org/0000-0002-2633-5883)
- Terence K. Lee (ORCID: https://orcid.org/0000-0003-0682-322X)
- Kristy Kwan‐Shuen Chan (ORCID: https://orcid.org/0000-0003-1445-7717)
- W.Y.Celia Yip
- Eva Yi-Man Fung
- Irene Oi‐Lin Ng (ORCID: https://orcid.org/0000-0001-7532-2029)
- Cheuk‐Yan Wong
- Regina Cheuk‐Lam Lo (ORCID: https://orcid.org/0000-0001-6213-0343)
- Long-Hin Suen
- K.K. Au
- Jing-Mian Zhang (ORCID: https://orcid.org/0000-0002-4976-3039)
Institutions
- Hong Kong Polytechnic University (HK)
- Chinese University of Hong Kong (HK)
- University of Hong Kong (HK)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1097/hc9.0000000000000778
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00