ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance
ASS1 deficiency causes an imbalance in the urea cycle and pyrimidine synthesis in liver cancer. ASS1 directly controls the ubiquitination of CAD via STUB1, rather than just competing with aspartate, thereby suppressing liver cancer. Thus, ASS1 has potential as a druggable target in liver cancer.
Authors
- Xiyuan Hu (ORCID: https://orcid.org/0009-0004-5767-2913)
- Zhiyong Luo (ORCID: https://orcid.org/0000-0002-5769-4387)
- Tiao Luo (ORCID: https://orcid.org/0009-0008-0575-5062)
- Jun‐Li Luo (ORCID: https://orcid.org/0000-0002-7625-4766)
- Zhengnan Ming
- Zizheng Zou (ORCID: https://orcid.org/0009-0004-5952-9299)
- Ling Chen (ORCID: https://orcid.org/0000-0003-4476-9711)
- Xiaohe Liu (ORCID: https://orcid.org/0000-0003-1297-9597)
- Jiang Zhou (ORCID: https://orcid.org/0000-0003-0858-4533)
- Jijia Li
- Da‐You Ma (ORCID: https://orcid.org/0009-0009-2390-5033)
- Suyou Liu (ORCID: https://orcid.org/0000-0002-1044-5332)
- Wensong Luo (ORCID: https://orcid.org/0009-0001-0642-8740)
- Liu Mingquan
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1097/hc9.0000000000000769
- Citations
- 5
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 4.03