Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos
Prenatal CPF exposure was associated with altered differentiation of neuronal tissue into cortical gray and white matter, increased myelination of the internal capsule, poorer motor performance, and profoundly impaired neuronal metabolism throughout the brain. CPF is known to increase oxidative stress and inflammation and in turn impair mitochondrial functioning, neuronal development, and maturation of the oligodendrocyte precursor cells responsible for axonal myelination. These molecular and cellular effects of CPF likely account at least in part for the observed associations of CPF with poorer long-term brain and motor outcomes.
Authors
- Howard Andrews (ORCID: https://orcid.org/0000-0002-7726-0551)
- Wanda Garcia
- Sahar Delavari (ORCID: https://orcid.org/0000-0001-8886-4484)
- Ravi Bansal (ORCID: https://orcid.org/0000-0003-4394-8355)
- Bradley S. Peterson (ORCID: https://orcid.org/0000-0001-5737-225X)
- Frederica P. Perera (ORCID: https://orcid.org/0000-0002-2263-7008)
- Siddhant Sawardekar (ORCID: https://orcid.org/0000-0003-3448-5184)
- Lori Hoepner (ORCID: https://orcid.org/0000-0002-4404-8140)
- Virginia Rauh (ORCID: https://orcid.org/0000-0003-3164-9892)
- Chaitanya Gupte (ORCID: https://orcid.org/0009-0008-6479-3050)
Institutions
- University of Southern California (US)
- Children's Health Fund (US)
- Children's Hospital of Los Angeles (US)
- NewYork–Presbyterian Hospital (US)
- SUNY Downstate Health Sciences University (US)
- Columbia University (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1001/jamaneurol.2025.2818
- Citations
- 7
- Primary Topic
- Pesticide Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 12.25