Potential pharmacokinetic interaction between enteral nutrition and valproic acid
Enteral nutrition may reduce the absorption of valproic acid. This could potentially result in subtherapeutic serum levels and worsen clinical outcomes.Clinicians should closely monitor serum levels and consider separating the administration of valproic acid and enteral nutrition by at least one hour.
Authors
- Iván Alejandro Díaz-Rengifo (ORCID: https://orcid.org/0000-0003-3959-8196)
- Ana Isabel Terleira Fernández
- María Rosario Salas-Butrón
- Natalí Giselle Lara-Gonzalez
Institutions
- Hospital Clínico San Carlos (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
Publication Details
- Journal
- European Journal of Case Reports in Internal Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.12890/2025_005657
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00