<scp>ILAE</scp> neuroimaging task force highlight: Tuberous sclerosis complex‐related epilepsy
The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Tuberous sclerosis complex (TSC) is a rare, complex, and multisystem autosomal dominant genetic disorder that arises from variations in the TSC1 or TSC2 genes. While characterized by a wide range of clinical manifestations, TSC commonly presents with epilepsy, which is a clinically challenging feature of the condition. Neuroimaging plays a pivotal role in the early diagnosis, screening, and long-term monitoring of TSC patients. CT serves as the first-line imaging tool in emergency settings; yet MRI is the primary diagnostic modality for TSC. In this report, we present two patients with TSC-related epilepsy and analyze their neuroimaging findings. We also address the diagnostic and therapeutic challenges faced by TSC patients with epilepsy.
Authors
- Boris C. Bernhardt (ORCID: https://orcid.org/0000-0001-9256-6041)
- Irène Wang (ORCID: https://orcid.org/0000-0002-3829-5217)
- Stefan Rampp (ORCID: https://orcid.org/0000-0002-4826-1520)
- Lorenzo Caciagli (ORCID: https://orcid.org/0000-0001-7189-9699)
- Paolo Federico (ORCID: https://orcid.org/0000-0002-9555-3569)
- Shuang Wang (ORCID: https://orcid.org/0000-0001-5211-9036)
- Eliane Kobayashi (ORCID: https://orcid.org/0000-0002-1713-1563)
- John S. Archer (ORCID: https://orcid.org/0000-0002-3939-3847)
- Gavin P. Winston (ORCID: https://orcid.org/0000-0001-9395-1478)
- William D. Gaillard (ORCID: https://orcid.org/0000-0001-5709-0033)
- Anna Elisabetta Vaudano (ORCID: https://orcid.org/0000-0002-6280-7526)
- Fernando Cendes (ORCID: https://orcid.org/0000-0001-9336-9568)
- Yotin Chinvarun (ORCID: https://orcid.org/0000-0003-3630-5423)
- Luis Concha (ORCID: https://orcid.org/0000-0002-7842-3869)
- Godwin Inalegwu Ogbole (ORCID: https://orcid.org/0000-0003-0431-7198)
- Xiao Chen (ORCID: https://orcid.org/0000-0001-5405-8695)
Institutions
- University of Modena and Reggio Emilia (IT)
- George Washington University Hospital (US)
- Montreal Neurological Institute and Hospital (CA)
- Cleveland Clinic (US)
- University of Calgary (CA)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Ibadan (NG)
- Queen's University (CA)
- University Hospital of Bern (CH)
- Phramongkutklao Hospital (TH)
- Universitätsklinikum Erlangen (DE)
- Southwestern Medical Center (US)
- Second Affiliated Hospital of Zhejiang University (CN)
- Austin Health (AU)
- Hotchkiss Brain Institute (CA)
- McGill University (CA)
- The University of Texas Southwestern Medical Center (US)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Epileptic Disorders
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1002/epd2.70087
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province